P3‐391: AMYLOID‐β DEPOSITION AND NEUROPSYCHOLOGICAL PROFILE IN ELDERLY WITH SUBJECTIVE COGNITIVE DECLINE AND SUPERAGERS: PRELIMINARY RESULTS
Bibliographic record
Abstract
Subjective cognitive decline (SCD) is a potential risk factor for dementia. On the other hand, the group recently known as “SuperAgers” (SA), elderly aged 80+ who have a memory equivalent to 20–30 years younger, present greater resilience to age-related cortical atrophy. Objective is to analyze and compare amyloid-β(Aβ) depositionandneuropsychological profile ofhealthy controls (HC), SCD and SA. SCD was defined by using a questionnaire for memory decline; for the diagnosis of SA it was required a performance at or above average normative values for individuals in their 50-60s in delayed recall score of the Rey Auditory Verbal Learning Test. Participants of the three groups were evaluated with the Clinical Dementia Rating scale (CDR), Mini Mental Status Examination (MMSE), Montreal Cognitive Assessment (MoCA), Brief Cognitive Screening Battery and a standard neuropsychological battery. Images of 11C-PIB were acquired in a hybrid PET/MR equipment and analyzed individually using cross-sectional images and with 3D-SSP methodology. For the between-groups comparison, we used the SPM8 software. Sixty-two elderly individuals (49 females) were included, being 17 HC, 37 SCD and eight SA. For the whole sample, mean age and schooling were 71.2 (±6.6) and 14.5 (±4.9) years, respectively. Differences were found between groups in the MoCA (SCD 24.1±2.2vs HC 25.4 ±2.5 vs SA 26.6 ±1.9, p = 0.01), but no MMSE (SCD 28.8 ±0.9 vs HC 29.1 ±0.9 vs SA 29.2 ±1.2, p = 0.338). There were no significant differences in other specific cognitive tests between SCD and HC. SCD exhibited no significant differences in Aβdeposition positivity when compared with HC (9/17 vs. 3/36, respectively). Unexpectedly, five from seven SA presented positive amyloid in visual analysis. In the comparison of age-adjusted groups, SA remained as the group with the greatest accumulation of amyloid. There was a higher prevalence in cortical amyloid deposition in SA in relation to other groups, but the small sample still limits the biomarker comparison between groups. The preliminary results suggest isolated amyloidosis is insufficient to lead to cognitive decline. This ongoing study is still recruiting volunteers.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".