P3‐397: CHARACTERIZATION OF LENTICULOSTRIATE ARTERIES USING ARTERIAL SPIN LABELING AND HIGH‐RESOLUTION 3D BLACK‐BLOOD MRI AS AN IMAGING MARKER IN VASCULAR COGNITIVE IMPAIRMENT AND DEMENTIA
Bibliographic record
Abstract
Small vessel disease is considered a systemic condition of aging resulting from dysfunction of arteriolar perfusion, which is exacerbated by vascular co-morbidities. We present an imaging-based evaluation of the lenticulostriate arteries (LSAs) and the perfusion in the middle cerebral artery perforator territory as it pertains to cognitive function in a cohort of elderly Latino subjects. 52 volunteers (13 male, 69±7 years) from the Los Angeles Latino Eye Study (LALES) cohort were scanned on a Siemens 3T Prisma scanner using a 20-channel head coil. The scan protocol included a 3D turbo spin echo with variable flip angles (T1w-VFA-TSE) sequence to visualize the LSAs and a 3D GRASE pseudo-continuous arterial spin labeling (pCASL) to evaluate cerebral blood flow (CBF). Quantitative CBF maps were calculated, and the LSA/MCA perforator territory region of interest (MCAperf) was extracted using our in-house Matlab scripts. History of vascular risk factors, Global Clinical Dementia Rating (Global CDR), MoCA, and NIH Toolbox scores were collected from 38 subjects. LSA delineation (LSAD) and MCAperf CBF were correlated pairwise with Pearson correlation. The interaction term between the mean LSAD rating and MCAperf CBF (LSAD*MCAperfCBF) was used in a multilevel mixed-effects generalized model to predict performance on NIH Toolbox tests, adjusted for age, gender, and global CBF. A two-sided Wilcoxon rank-sum test determined if the median LSAD*MCAperfCBF was significantly different for patient vascular risk factors and Global CDR. Figure 1 shows correlation for right MCAperf CBF (p=0.039) and LSAD. LSAD*MCAperfCBF was significantly positively correlated with MoCA z-score and various executive function scores for NIH Toolbox tests (Figure 2). Figure 3 shows boxplots for Global CDR and history of hyperlipidemia, with higher median LSAD*MCAperfCBF for normal subjects. Figure 4 shows an example of 2 subjects’ LSAs and their clinical data. With poorer vessel quality, MCAperfCBF, plus vascular risk factors, cognitive function appears to decline.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".