Computational fluid dynamics as aid tool for the management of aortic wall diseases
Bibliographic record
Abstract
Aortic aneurysms and dissections are pathological conditions affecting the aorta. Despite being different in clinical presentation, these pathologies share a high mortality rate, as well as a lack of reliable prognostic predictors. Local fluid dynamics is assumed to play a role in aortic patho-physiology and to be a key factor responsible for aortic weakening and expansion. In this context, the numerical modeling of aortic hemodynamics, by means of image-based computational fluid dynamics (CFD), gives access to patient-specific flow-related information that may complement medical imaging in the assessment of individual aortas and support outcomes prediction. Moreover, the deformability of the aortic wall appears to be related to its strength: areas at elevated strain may, therefore, indicate structural weakening. Based on these understandings, this research work proposes the use of hemodynamic descriptors, derived from CFD simulations, to correlate local altered flow patterns with aortic remodeling and weakening, and ultimately help defining a rationale for improved rupture risk stratification. Wall shear stress-based hemodynamic descriptors were used to retrospectively assess a population of uncomplicated type B aortic dissections (ADs) with known individual outcomes. The effect of rigid versus moving wall assumption on aortic flow patterns was explored by means of fluid-structure interaction (FSI) simulation. The results highlighted the need for a patient-tailored approach when evaluating ADs, and showed the potential of CFD-derived hemodynamics to complement anatomical assessment and assist outcomes prediction. The inclusion of wall motion in the simulation of a type B AD, led to differences in value for the hemodynamic wall descriptors, however, regions of interest with respect to altered flow patterns were consistently localized by both the CFD and FSI models. Finally, a combined CFD and in-vivo strain analysis approach was developed to assess local weakening and rupture risk for a population of AAAs. A novel index, Regional Rupture Potential, was defined and proved able to capture aortic regional weakening. This thesis demonstrated the importance of accessing hemodynamic information when assessing individual aortas with prognostic purposes, along with the potential of a novel combined approach to improve aortic assessment for risk stratification.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".