Radon, cigarette smoking, and the risk of coronary heart diseases in the Newfoundland Fluorspar miner’s cohort study with follow-up from 1950 through 2016
Bibliographic record
Abstract
TPS 791: Occupational health 1, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM Background: Radon is an established lung carcinogen, and findings of occupationally exposed miners have played an important role in characterizing the exposure-response relationship curve. Nonetheless, there remain uncertainties regarding risks associated with coronary heart diseases, including risks at low-levels of exposure, interactions with cigarette smoking, and changes in risk with increasing latency. To address these research questions, we performed an analysis of a cohort of Newfoundland Fluorspar miners whose mortality experience was followed up from 1950 through 2016. Methods: Analyses were performed on 2,121 miners who were employed in the mining of fluorspar between 1933 and 1978 in St. Lawrence Newfoundland. Cause of death information was determined through record linkage to the Canadian Mortality Database through December 31, 2016. Cumulative radon exposure estimates in working levels months (WLM), by year, were assigned to each cohort member, and four cycles of smoking survey (1966, 1978, 1993, & 2003) were conducted. The Cox-proportional hazard ratio (HR) models were applied to characterize the risk across levels of exposure, adjusting-for cigarette smoking, and attained age. Results: A total of 378 deaths were due to coronary heart disease. The mean occupational exposure to radon was 378 WLM over an average of 5.5 exposure years. The incidence rate of coronary heart disease amongst miners exposed at higher levels compared to the lowest levels is 4.97 vs. 3.51 per 1000 person-years. The adjusted HR between these two categories of exposure is 1.53 (95% CI: 1.07 – 2.18), with no presence of effect-modification by smoking. Conclusions: The long follow-up interval of this cohort now spans nearly 8 decades and provides insight on the risks of coronary heart disease in relation to time-varying aspects of radon exposure. Some of our findings should be interpreted cautiously due to increased exposure measurement error during the earlier stages of the follow-up period.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".