P5542Predictors of the risk of recurrent cardiovascular events in patients with unstable angina with conservative treatment strategy
Bibliographic record
Abstract
Abstract Objective To identify independent predictors of the risk of recurrent cardiovascular events in patients (pts) with unstable angina (UA) in a conservative treatment strategy. Material and methods The study involved 236 patients with UA with low risk according to GRACE scale and conservative treatment strategy. The end points were: recurrent UA, myocardial infarction (MI), death. The mean age was 60.2±7.3 years. All pts were performed general blood analysis, determination of troponin I, BNP, C-reactive protein, myeloperoxidase, von Willebrand factor, fibrinogen, antithrombin III and also the performance of the thrombin generation test, aggregatogram on aggregometry Multiplate impedance and ECG, EchoCG, Holter ECG. Results Cardiovascular events developed in 104 (44%) pts during 5 years of follow-up, and in the first year of follow - up-in 58 people (24.6%), followed annually by 10–14% of events for the year. MI developed in 21 pts (8.9%), recurrent angina in 75 (31.8%) pts, 51 (21.6%) pts underwent coronary artery stenting, and 26 (11%) pts underwent coronary bypass surgery, 8 (3.4%) patients died. Having studied all the objective data of the observed patients, we concluded that independent predictors of the risk of recurrent cardiovascular events were: previous MI (RR=2,8; 95% CI 1,32–6,08; p=0,0028), type II Diabetes (RR=3,1; 95% CI 1,78- 5,37; p=0,0001), first-time angina pectoris (RR=3,7; 95% CI 2,68–5,85; p=0,001, smoking (RR=2,1; 95% CI 1,21–3,74; p=0,0129), baseline myeloperoxidase >316 pmol/l (RR=3,1; 95% CI 1,29–4,74; p=0,029), high sensitive CRP >3,8 g/l (RR=3,9; 95% CI 2, 44–6,14; p=0,0001), mean platelet volume >9,6fl (RR=2,9; 95% CI 1,49–5,52; p=0,0006), area under the curve ADP- test AUC >60 U (RR=3,4; 95% CI 2, 3–5,2; p=0,002). Conclusions Cardiovascular events developed in 44% of pts over 5 years of follow-up. Independent predictors of adverse outcomes in pts with UA with low risk according to GRACE scale were: previous MI, type II Diabetes mellitus, first-time angina pectoris, smoking, baseline myeloperoxidase levels>316 pmol/l, highly sensitive CRP>3.8 g/l, MPV>9.6fl, and the area under the ADP test curve >60 U.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".