Current developments in <i>Coot</i> for macromolecular model building of Electron Cryo‐microscopy and Crystallographic Data
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Abstract
Coot is a tool widely used for model building, refinement, and validation of macromolecular structures. It has been extensively used for crystallography and, more recently, improvements have been introduced to aid in cryo-EM model building and refinement, as cryo-EM structures with resolution ranging 2.5-4 A are now routinely available. Model building into these maps can be time-consuming and requires experience in both biochemistry and building into low-resolution maps. To simplify and expedite the model building task, and minimize the needed expertise, new tools are being added in Coot. Some examples include morphing, Geman-McClure restraints, full-chain refinement, and Fourier-model based residue-type-specific Ramachandran restraints. Here, we present the current state-of-the-art in Coot usage.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Protein Science
- Topic
- Enzyme Structure and Function
- Field
- Materials Science
- Canadian institutions
- —
- Funders
- FP7 People: Marie-Curie ActionsMedical Research CouncilRöntgen-Ångström ClusterMedical Research Council CanadaEuropean CommissionMarie CurieUK Research and InnovationEuropean Molecular Biology Organization
- Keywords
- MorphingModel buildingComputer scienceCrystallographyArtificial intelligencePhysicsChemistry
- Has abstract in OpenAlex
- yes