CONSERVATION OF INTEGRATIVE PHYSIOLOGICAL AGING MECHANISMS ACROSS PRIMATES
Bibliographic record
Abstract
Abstract Physiological dysregulation (PD) and integrated albunemia (IA) are organism-level aging mechanisms that can be measured using standard biomarkers, and in humans they have been shown to increase with age and predict health outcomes. Here, we use 10 species from the Internet Primate Aging Database (iPAD), a longitudinal database of biomarkers and mortality in captive primates, to analyze the generalizability of the role of PD and IA in aging, as well as the conservation of the underlying physiology. Human patterns are broadly but not universally replicated in primates. For example, PD increases with age in nine of eleven species, and predicts mortality in three of four. Both IA and PD can to some extent be cross-calibrated across species, indicating surprising conservation of underlying homeostatic norms; in the case of PD, the calibration weakens with phylogenetic distance.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".