EFFECTS OF PRENATAL AND POSTNATAL EXPOSURE TO CHLORDECONE ON INFANT NEURODEVELOPMENT
Bibliographic record
Abstract
Background and Aims: The estrogenic insecticide chlordecone was extensively used from 1973 to 1993 in the French West Indies, to control banana root borer. Its persistence in soils has led to the widespread pollution of the environment including tap water sources and crops. Chlordecone was shown to have neurological effects in humans such as tremor, ataxia, oculomotor dysfunctions and memory loss. Thus, the aim of the study was to evaluate the impact of prenatal and postnatal exposure to chlordecone on the neurodevelopment of 7-month-old infants from Guadeloupe. Methods: Umbilical cord blood samples (n=169) were collected from newborns and analyzed for chlordecone concentrations (mean = 0.58 ng/L). Infants were tested at 7 months. Visual recognition memory and speed of processing visual information into memory were assessed with the Fagan Tests of Infant Intelligence (FTII), visual acuity with the Teller Acuity Card test and fine motor development with the Brunet Lezine. A maternal interview was conducted to document infant health, diet and family situation. Chlordecone concentrations were quantified in breast milk. Postnatal exposure was determined through frequency of contaminated food consumption by the infants. Results: In adjusted models, cord chlordecone concentrations in tertile were associated with reduced novelty preference on the FTII in the highly exposed group (β=-0.22, p=0.005), as was consumption of contaminated food (β=-0.15, p=0.038). Postnatal exposure through contaminated food consumption was also related to longer time to process visual information (β=0.18, p=0.045). Detectable levels of chlordecone in cord blood were associated with higher risk of having a score below the third percentile on the fine motor development scale (OR=1.27, p=0.002). Chlordecone in breast milk was not associated with neurodevelopment scores. Conclusion: These results suggest that pre- and postnatal low chronic exposure to chlordecone is associated with deleterious effects on several domains of neurodevelopment during infancy.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".