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Temporal Variation of Total Mercury Levels in the Hair of Pregnant Women from the MIREC (Maternal-Infant Research on Environmental Chemicals) Study

2018· article· en· W2991109138 on OpenAlexaffabout
Anna Lukina, Cheryl Khoury, John Than, Mireille Guay, Jean-François Paradis, Mandy Fisher, Tye E. Arbuckle

Bibliographic record

VenueISEE Conference Abstracts · 2018
Typearticle
Languageen
FieldEnvironmental Science
TopicMercury impact and mitigation studies
Canadian institutionsHealth Canada
Fundersnot available
KeywordsMercury (programming language)PregnancyBreast milkCord bloodUmbilical cordScalpMeconiumFetusPhysiologyMedicineObstetricsMethylmercuryChemistryBiologyInternal medicineImmunologySurgeryEnvironmental chemistryBiochemistry

Abstract

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Prenatal exposure to mercury (T-Hg) comes from both natural and anthropogenic sources. T-Hg can cross the blood-placental barrier, transfer from mother to fetus, and may be associated with future neurological (memory loss, personality changes, deafness and vision loss, attenuation of IQ) and physiological (delays in walking and talking, tremors and convulsions) dysfunctions. Hair is an optimal and non-invasive indicator of chronic T-Hg exposure. On average, scalp hair grows about 1.1 cm per month. As part of the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, hair samples of 350 women were collected within weeks after giving birth, to determine temporal variation of T-Hg from conception to delivery, and to compare these levels to levels measured in other matrices (maternal and umbilical cord blood, breast milk, and infant’s meconium). One centimeter sequential hair samples were collected, starting at the scalp and up to 12 cm. Overall, T-Hg levels decreased over the course of pregnancy. Mercury levels in hair positively correlated with levels in blood, but not with levels in meconium or breast milk. A higher mean mercury level was found in cord blood, meaning that it was able to pass the placental barrier, but did not reach the fetus, since the majority of meconium samples had mercury below the detection limit. This study generates knowledge on the monthly variation of mercury in a pan-Canadian pregnancy cohort and provides a unique opportunity to compare mercury levels from multiple matrices from pregnant women and their infants.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.583
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.090
GPT teacher head0.341
Teacher spread0.251 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2018
Admission routes2
Has abstractyes

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