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Record W2992370223 · doi:10.3390/app9245318

Magnetic Fields Trump Oxygen in Controlling the Death of Erythro-Leukemia Cells

2019· article· en· W2992370223 on OpenAlexaff
Ying Li, Paul Héroux

Bibliographic record

VenueApplied Sciences · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicElectromagnetic Fields and Biological Effects
Canadian institutionsMcGill UniversityMcGill University Health Centre
Fundersnot available
KeywordsApoptosisProgrammed cell deathIncubatorHuman lifeCellCancer cellHuman healthCancerCell biologyChemistryBiologyImmunologyMedicineEnvironmental healthMicrobiologyInternal medicineBiochemistryPolitical science

Abstract

fetched live from OpenAlex

Expansions in power and telecommunications systems have created a new electromagnetic environment. Here, we compare the death rate of human cancer cells in vitro in the pre-industrial electromagnetic environment of the past (“Zero Field”) with that of an electromagnetic environment typical of contemporary human exposures (“Incubator Field”). A cell incubator provides magnetic fields comparable to those in the current human environment. Steel shields divert those same fields away from cell preparations in the “pre-industrial” assays. Large changes in oxygen levels are provided by nitrogen or atmospheric gas over the cell cultures. Human cancer cells are then separated according to three categories: necrotic, early apoptotic, or late apoptotic. The results are compiled for two variables, magnetic field and oxygen, in 16 different situations (“Transitions”) likely to occur in the human body under present living conditions. We find that magnetic fields are a more powerful determinant of cell death than oxygen, and induce death by different mechanisms. This has important implications for the reproducibility of in vitro biological experiments focusing on cell survival or metabolism, and for public health. The rate and mechanisms of cell death are critical to many chronic human ailments such as cancer, neurological diseases, and diabetes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.022
Threshold uncertainty score0.205

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.215
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2019
Admission routes1
Has abstractyes

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