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External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial
Timothy J. Whelan, Jim A. Julian, Tanya Berrang, Do‐Hoon Kim, Isabelle Germain, Alan Nichol, Mohamed Akra, Sophie Lavertu, François Germain, Anthony Fyles, Theresa Trotter, Francisco Perera, Susan Balkwill, Susan Chafe, Thomas McGowan, Thierry Muanza, Wayne Beckham, Boon Chua, Chu Shu Gu, Mark N. Levine, Ivo A. Olivotto, Carson Leong, Beverly Lester, Winkle Kwan, Medhat Zikry Abd-El-Malek, Arthur Cheung, Maha Almahmudi, J.A. Broomfield, Michael Sia, Melanie Reed, J. Frank Wilson, Islam Mohamed, Caroline Holloway, Ken Mills, David Petrik, Juanita Crook, Frances Wong, Hannah Carolan, D. Voduc, Paris‐Ann Ingledew, Sonia Nguyen, Mira Keyes, Lorna Weir, Scott Tyldesley, Peter Lim, Christina Parsons, Robert Olson, Paul Blood, Elaine S. Wai, Pauline T. Truong, Hosam A. Kader, Abraham Alexander, Aminudin R. Mydin, Sally Smith, María T. Vlachaki, Valérie Panet-Raymond, Krystine Lupe, Jennifer Goulart, David H. Nguyen, Karen Chu, Joycelin Canavan, Julianna Caon, Susan A. Tyler, Negin Shahid, Jacqueline Lam, John Amanie, Diane Severin, Bassam Abdul Karim, Keith Tankel, Nadeem Pervez, Kurian Joseph, Zsolt Gabos, Barbara Krause, Fleur Huang, Tien Phan, Peter Craighead, Elizabeth Yan, Jill MacKinnon, Robert Nordal, Siraj Husain, Jon-Paul Voroney, Richie Sinha, James Pinilla, Andrew Cooke, Kalyani Vijayraghavan, Steven Latosinsky, Elizabeth Saettler, Yiu-Keung Lau, Marianne Krahn, Ethel MacIntosh, Maged N. F. Nashed, Bashir Bashir, Benjamin A. Goldenberg, Christina Kim, V. Basrur, Ramana Rachakonda, Darin Gopaul, Sundeep Shahi, Sofya Kobeleva, Ian S. Dayes, David Hodson, Barbara Strang, S. Voruganti, William McMillan, Harold Reiter, Jonathan Sussman, Som D. Mukherjee, Susan Gudelis, David D’Souza, Michael Lock, Nancy Read, Olga Vujovic, Brian Yaremko, Edward Yu, Theodore A. Vandenberg, Jawaid Younus, Kylea Potvin, Tracy Sexton, B. Dingle, B. Findlay, Janice Giesbrecht, Philip F. Hughes, Martin Samosh, Michael A. Levesque, Radhika Yelamanchili, Linda Lee, R Vandermeer, David H. Wasserman, Julie Bowen, David Want, Randall Bissett, A. Andronowski, Sarwat Shehata, Hugh L. Prichard, Wayne Koll, Philip C. Y. Chan, Jimmy Mui, Youssef M. Youssef, Holly R. Campbell, Medhat El-Mallah, Fawaad Iqbal, Behzad Banihashemi, Peter Dixon, L. Grimard, C. Lochrin, Joanne Meng, P. Cross, Samy El‐Sayed, B. Esche, P. Genest, Jean-Michel Caudrelier, Scott C. Morgan, Jean‐Marc Bourque, Vimoj Nair, Senti Senthelal, Glenn Jones, Jonathan Tsao, John Radwan, Charles Hayter, Marisa Finlay, JD Lian, Yongjin Wang, Jasper Yuen, Luleul Khan, B.C. John Cho, Christine Koch, Fei‐Fei Liu, L. Manchul, Michael McLean, Pamela Catton, Robert Dinniwell, Woodrow Wells, Wilfred Levin, Lorraine Walsh, Caroline Chung, Kathy Han, Tatiana Conrad, Joelle Helou, Aisling Barry, K Schneider, Khalid Hirmiz, Hakam Abu-Zahra, Isabelle Roy, Jose Ayllon, Pierre Del Vecchio, Marie-Andrée Fortin, Jean‐Pierre Guay, F Méthot, Pierre Rousseau, M. Jolicoeur, Toni Vu, Levon Igidbashian, Anne Dagnault, Luis-Victor Diaz de Bedoya, Chang Shu Wang, A. Fortin, Éric Vigneault, Isabelle Vallières, Paul-Émile Raymond, André‐Guy Martin, Lucie Blondeau, Marie Larochelle, N. Lessard, M Gaudreault, Valérie Théberge, Abdenour Nabid, Olivier Ballivy, Rachel Bujold, Annie Ébacher, Sawyna Provencher, Pierre Chabot, Céline Lemaire, Peter Vavassis, C. Menkarios, Michael Yassa, Khalil Sultanem, Lawrence Panasci, David Melnychuk, François Patenaude, Wilson H. Miller, Catalin Mihalioiu, P.D. Ahlgren, Richard Dalfen, Adrian Langleben, Donna Stern, Jonathan Wan, Christine Lambert, Marc David, Neil Kopek, Annie Carbonneau, Tarek Hijal, Nancy J. Grant, Farah Naz, M. Mohiuddin, Sri Kumar, Robert Rutledge, D. Rheaume, Maureen Nolan, Wladyslawa Cwajna, Suki Gill, Tracie Gleisner, Solveig Grenfell, Michelle Bishop, Niluja Thiruthaneeswaran, Chen Liu, Claire Philips, Roslyn Drummond, Bronwyn King, Steven David, Mary Dwyer, Gillian Campbell, Susan A. Brooks, Ramesh Arunachalam, Giuseppe Sasso, Chelleraj Benjamin, Chakiath Jose, Christine Elder, Hedley Krawitz, Dominique Lee, Roger Huang, Sudha Purchuri, Maria Pearse, Thayavalappil Hemanth, Ruth Angell, Vikash Patel, Glenys Round, Anupam Chaudhuri, C. H. J. Ford
Bibliographic record
VenueThe Lancet · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBreast Cancer Treatment Studies
Canadian institutionsUniversity of VictoriaMcGill UniversityCredit Valley HospitalUniversity of AlbertaWestern UniversityUniversity of TorontoUniversity of British Columbia, Okanagan CampusPrincess Margaret Cancer CentreUniversity of CalgaryCentre Hospitalier de l’Université de MontréalUniversité LavalSurrey Memorial HospitalUniversity of British ColumbiaMcMaster UniversityJewish General HospitalKelowna General HospitalTrillium Health CentreUniversity of ManitobaJuravinski Cancer Centre
Fundersnot available
KeywordsMedicineBreast cancerBreast-conserving surgeryDuctal carcinomaHazard ratioBreast surgeryRandomized controlled trialMastectomySurgeryUrologyConfidence intervalCancerInternal medicine
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.013
Threshold uncertainty score0.044
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.005 | 0.004 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.003 | 0.004 |
| Insufficient payload (model declined to judge) | 0.013 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.012
GPT teacher head0.238
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations424
Published2019
Admission routes1
Has abstractno