Relationship of serum magnesium level with body composition and survival in hemodialysis patients
Bibliographic record
Abstract
Abstract Introduction A relationship between serum magnesium (Mg) and body composition parameters has not been reported in hemodialysis (HD) patients. We aimed to clarify whether serum Mg has any association with body composition parameters, or survival in HD patients. Methods This study included 215 consecutive maintenance HD patients. Laboratory data collection and postdialysis body composition analysis were performed at baseline. The patients were divided based on baseline serum Mg level tertiles (low, medium, and high Mg groups). Kaplan–Meier survival, logistic regression analyses and Cox proportional hazard analyses were conducted. Findings Among all patients, the median age and dialysis vintage were 73 (65–81) years and 44 (8–96) months, respectively. The serum Mg levels were < 2.3, 2.3–2.5, and > 2.5 mg/dL for the low (n = 67), middle (n = 76), and high (n = 72) Mg groups, respectively. Compared to other groups, low Mg group showed significantly higher age and C‐reactive protein levels, but lower serum albumin, normalized protein catabolic rates and frequency of on‐line hemodiafiltration. The low, middle, and high Mg groups differed significantly regarding body cell mass (fat‐free mass without bone mineral mass and extracellular water) index (BCMI): [5.6 (4.2–6.8), 6.0 (4.8–8.1), 6.7 (4.9–7.5) kg/m2, respectively] and overhydration/extracellular water ratio (OH/ECW) [11.7 (4.5–21.9), 4.8 (1.0–14.1), 8.5 (−0.5–15.0) %, respectively] but not regarding body mass index, lean tissue index, fat tissue index. Hypomagnesemia was significantly associated with BCMI [odds ratio (OR) [95% confidence interval (CI)]: 0.85 [0.73–1.00] and OH/ECW (OR [95% CI]: 1.03 [1.01–1.05]), respectively. Kaplan‐Meyer 3‐year survival rates were 53.6%, 69.7%, and 71.7% in low, middle, and high Mg groups, respectively. However, hypomagnesemia was not significantly associated with 3‐year all‐cause mortality independent of age, serum albumin and C‐reactive protein. Discussion Hypomagnesemia was associated with lower BCMI, more pronounced OH/ECW and poorer Kaplan–Meier 3‐year cumulative survival, but was not an independent risk factor for mortality in HD patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".