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Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

2019· article· en· 1,213 citations· W2993083975 on OpenAlex· 10.1016/s0140-6736(19)33041-7

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.034
GPT teacher head0.339
Teacher spread
0.305 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
The Lancet
Topic
Liver Disease Diagnosis and Treatment
Field
Medicine
Canadian institutions
University of Alberta
Funders
AstraZenecaAllerganGilead SciencesServierNovartis PharmaNewcastle UniversityNovo NordiskAbbott LaboratoriesNational Institute for Health and Care ResearchGenentechArrowhead PharmaceuticalsCoherus BiosciencesIntercept PharmaceuticalsAlexion PharmaceuticalsMedpaceGlaxoSmithKlineNGM BiopharmaceuticalsBirmingham Biomedical Research CentrePfizerCelgeneEli Lilly and CompanyBristol-Myers SquibbChildren's Liver Disease FoundationSanofi
Keywords
Obeticholic acidInterim analysisMedicinePlaceboSteatohepatitisInterimInternal medicineFatty liverClinical trialDiseaseAlternative medicinePolitical sciencePathology
Has abstract in OpenAlex
no