Evaluation of the efficacy for pain relief of intra articular Hyaluronate injections in knee osteoarthritis
Bibliographic record
Abstract
Background: Osteoarthritis (OA) is the most common age-related degenerative joint disease in the world. Most current pharmacological options are limited to alleviating pain and improving function. Viscosupplementation with intra-articular sodium hyaluronate offers another approach to the treatment by addressing the degradation of hyaluronic acid (HA) in the synovial fluid by the addition of exogenous HA, resulting in pain reduction and functional improvement. The primary purpose of this study is to evaluate the efficacy of 20mg/2ml Sodium Hyaluronate for relieving the symptoms of knee OA in an Indian setting.Materials & Methods: Forty five patients with symptomatic osteoarthritis diagnosed as Kellgren-Lawrence Grade I/II not responding to conservative management were administered three intra articular injections of Sodium Hyaluronate at weekly intervals. The subjects were followed up for 28 weeks and assessed by administering Western Ontario and McMaster University Osteoarthritis Index (WOMAC) Modified CRD-Pune version (LK3.1).Results: We noted a decrease in the Pain subscore of WOMAC from 6.07±1.23 to 2.48±0.63 between Week 0 and Week 28, considered statistically highly significant. Overall, total WOMAC score decreased significantly between Week 0 and Week 28. The commonly encountered adverse effect was injection site pain, seen in 33.3% of patients at Week 1, and 64.4% of patients at Week 2.Conclusion: We found that viscoelastic supplementation with three intra articular injections of Sodium Hyaluronate at weekly intervals is a simple, safe, effective and minimally invasive modality for conservative treatment of Early Grade (I & II) Osteoarthritis of the knee joint.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".