MétaCan
Menu
Back to cohort
Record W2994407421 · doi:10.1016/j.dadm.2019.08.003

Nonlinear Z‐score modeling for improved detection of cognitive abnormality

2019· article· en· W2994407421 on OpenAlexaff
John Kornak, Julie A. Fields, Walter K. Kremers, Sara A. Farmer, Hilary W. Heuer, Leah K. Forsberg, Danielle Brushaber, Amy Rindels, Hiroko H. Dodge, Sandra Weıntraub, Lilah M. Besser, Brian S. Appleby, Yvette Bordelon, Jessica Bove, Patrick Brannelly, Christina Caso, Giovanni Coppola, Reilly Dever, Christina Dheel, Bradford Dickerson, Susan Dickinson, S. Carbajal Domínguez, Kimiko Domoto‐Reilly, Kelley Faber, Jessica Ferrall, Ann Fishman, Jamie Fong, Tatiana Foroud, Ralitza H. Gavrilova, Deb Gearhart, Behnaz Ghazanfari, Nupur Ghoshal, Jill Goldman, Jonathan Graff‐Radford, Neill R. Graff‐Radford, Ian Grant, Murray Grossman, Dana Haley, John Hsiao, Ging‐Yuek Robin Hsiung, Edward D. Huey, David J. Irwin, David T. Jones, Lynne C. Jones, Kejal Kantarci, Anna Karydas, Daniel Kaufer, Diana Kerwin, David S. Knopman, Ruth Kraft, Joel H. Kramer, Walter A. Kukull, Maria I. Lapid, Irene Litvan, Peter A. Ljubenkov, Diane Lucente, Codrin Lungu, Ian R. Mackenzie, Miranda Maldonado, Masood Manoochehri, Scott McGinnis, Emily McKinley, Mario F. Mendez, Bruce L. Miller, Namita Multani, Chiadi U. Onyike, Jaya Padmanabhan, Alexander Pantelyat, Rodney Pearlman, Len Petrucelli, Madeline Potter, Rosa Rademakers, Eliana Marisa Ramos, Katherine P. Rankin, Katya Rascovsky, Erik D. Roberson, Emily Rogalski-Miller, Pheth Sengdy, Les Shaw, Adam M. Staffaroni, Margaret Sutherland, Jeremy A. Syrjanen, Maria Carmela Tartaglia, Nadine Tatton, Joanne Taylor, Arthur W. Toga, John Q. Trojanowski, Ping Wang, Bonnie Wong, Zbigniew K. Wszołek, Bradley F. Boeve, Adam L. Boxer, Howard J. Rosen

Bibliographic record

VenueAlzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 2019
Typearticle
Languageen
FieldDecision Sciences
TopicPsychometric Methodologies and Testing
Canadian institutionsUniversity of British ColumbiaUniversity of Toronto
FundersNational Institute of Biomedical Imaging and BioengineeringNational Institute of Neurological Disorders and StrokeNational Cancer InstituteNational Institute on AgingAvid RadiopharmaceuticalsNational Institutes of HealthRainwater Charitable FoundationBiogenCenters for Disease Control and PreventionBristol-Myers SquibbEli Lilly and CompanyAstraZenecaAssociation for Frontotemporal DegenerationNational Heart, Lung, and Blood InstitutePfizerU.S. Department of Defense
KeywordsNormativeStandard deviationCognitionResidualNonlinear systemMathematicsStatisticsAbnormalityVariance (accounting)Standard scorePsychologyEconometricsDevelopmental psychologyAlgorithmSocial psychology

Abstract

fetched live from OpenAlex

INTRODUCTION: Conventional Z-scores are generated by subtracting the mean and dividing by the standard deviation. More recent methods linearly correct for age, sex, and education, so that these "adjusted" Z-scores better represent whether an individual's cognitive performance is abnormal. Extreme negative Z-scores for individuals relative to this normative distribution are considered indicative of cognitive deficiency. METHODS: In this article, we consider nonlinear shape constrained additive models accounting for age, sex, and education (correcting for nonlinearity). Additional shape constrained additive models account for varying standard deviation of the cognitive scores with age (correcting for heterogeneity of variance). RESULTS: . DISCUSSION: Nonlinearly corrected Z-scores with respect to age, sex, and education with age-varying residual standard deviation allow for improved detection of non-normative extreme cognitive scores.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.016
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.013
Threshold uncertainty score0.026

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.016
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.288
GPT teacher head0.459
Teacher spread0.171 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations26
Published2019
Admission routes1
Has abstractyes

Explore more

Same venueAlzheimer s & Dementia Diagnosis Assessment & Disease MonitoringSame topicPsychometric Methodologies and TestingFrench-language works237,207