Evaluating Glutathione Peroxidase Activity as a Marker of Cognitive Impairment in Coronary Artery Disease Patients
Bibliographic record
Abstract
Coronary artery disease (CAD) patients are at risk for vascular cognitive impairment (VCI), yet mechanisms remain elusive. We hypothesized that glutathione peroxidase activity (GPx), which protects from oxidative damage, would be higher in CAD patients with cognitive impairment (n=36) compared to those without (n=84), and baseline GPx and change in GPx over 6 months would be associated with changes in verbal memory. CAD patients were recruited from the Toronto Rehabilitation Institute Cardiac Rehab (TRI-CR) program. Cognitive performance and GPx activity were measured at baseline and 6-month timepoints. GPx was significantly elevated in those with cognitive impairment (F1,119=3.996, p=0.048). While a 1 nmol/min/mL increase in GPx activity was associated with a decrease in verbal memory z-scores by 0.02 standard deviations (SD) over 6 months (b=-0.02, df=184.65, p=0.004), baseline GPx did not predict change in verbal memory. This research suggests that alterations in GPx activity may be associated with cognition in CAD patients.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".