Antimicrobial, anti-cancer, anti-filarial and anti-inflammatory activities of Cowabenzophenone A extracted from the endophytic fungus <i>Aspergillus terreus</i> isolated from a mangrove plant <i>Bruguiera gymnorrhyza</i>
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Cowabenzophenone A was isolated from an endophytic fungus Aspergillus terreus isolated from a mangrove plant Bruguiera gymnorrhyza. The structure was determined by analysis of 1D and 2D NMR spectra and mass spectrometric data as a tetracyclo[7.3.3.33,11.03,7]tetradecane-2,12,14-trione skeleton. When the compound was tested in vitro for its ability to inhibit inflammations, α-glucosidase inhibitory activities and its antimicrobial properties, it showed an anti-inflammatory activity amounting to an IC50 of 12.1 µg/mL, α-glucosidase inhibitory activity, with IC50 values of 7.8 ± 0.5 μM, and antibacterial activity against Bacillus subtilis TISTR 088, and Bacillus cereus TISTR 688 with MIC values of 1 μg/mL and 2 μg/mL respectively. The compound showed cytotoxicity against HCT 116 colon cancer cell line with an IC50 value of 10.1 ?M, and also showed a considerably high potential towards anti-filarial activities by resulting MIC, IC50 and LC50 values of 0.358 ± 0.02 mg/mL, 0.708 ± 0.021 mg/mL and 3.89 ± 0.18 mg/mL, respectively, in comparison to the standard drug Ivermectin (IVM).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it