The relationship between fat mass and obesity-associated gene polymorphism and obesity among children in China: A systematic review and meta-analysis
Bibliographic record
Abstract
The fat mass and obesity-associated (FTO) gene has been shown to be associated with obesity in different populations. However, this association in the Chinese population has been controversial. We evaluated the association of the FTO rs9939609 gene polymorphism with the risk of overweight and obesity in Chinese children and adolescents in a systematic review and meta-analysis. We searched PubMed, Embase, Cochrane Library, and two electronic Chinese databases (CBM, CNKI). Two authors screened abstracts, full-texts, and extracted data according to the prespecified inclusion criteria. A modified STREGA score was used for quality assessment. A random-effects and fixed-effects model was used to conduct the measure the association between FTO gene and obesity. Ten studies including 12,879 participants were included. The FTO rs9939609 gene polymorphism was associated with a statistically significant increased risk of obesity or overweight in Han Chinese children and adolescents (P < 0.05), but absent in the Zhuang and Hazakh Chinese population (P > 0.05). The pooled OR for the codominant genetic model between AA and TT was 1.79 (95% confidence interval: 1.34–2.39, P < 0.0001). Allele A carriers were at greater risk of obesity and overweight compared to noncarriers. Screening for FTO rs9939609 gene polymorphism might help to identify adolescents at risk of developing obesity and consider appropriate prevention strategies.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.006 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".