Trimetazidine Instable angina pectoris and Type 2 Diabetes Mellitus: Safety & Effectiveness: A Descriptive study
Bibliographic record
Abstract
An observational, non interventional, open-label clinical study assessed the effectiveness/safety of trimetazidine in 101 patients with stable angina pectoris and Type 2 diabetes mellitus. Results: Trimetazidine-based therapy was effective in stable coronary artery disease, with significant improvements from baseline (p < 0.05) in: number of angina attacks/week (2.9 2.4 vs 1.1 1.6), angina severity (Canadian Cardiovascular Society Classification 1.9 0.8 vs 1.2 0.8), exercise capacity (metabolic equivalents 6.8 1.7 vs 6.5 1.7), and exercise-induced myocardial ischemia (min 5.5 2.5 vs 6.5 2.6). Discussion: Trimetazidine treatment significantly (p < 0.05) improved glucose metabolism, lowered HbA1c (7.1 1.1% vs 6.6 1.0%), glucose levels (7.7 2.1 mmol/l vs 6.9 1.6 mmol/l) and decreased arterial stiffness (pulse wave velocity 11.2 2.1 m/s vs 10.4 2.2 m/s). In most patients, the tolerability of trimetazidine was rated as excellent to good, with a low incidence of adverse events.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.057 | 0.026 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".