MétaCan
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Clinical Impact of Metagenomic Next-Generation Sequencing of Plasma Cell-Free DNA for the Diagnosis of Infectious Diseases: A Multicenter Retrospective Cohort Study

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Observational
Classifier consensus
Observational
Teacher imitation scores

Codex

Observational1.000
Metaresearch0.002
Simulation or modelling0.002
Science and technology studies0.001
Bench or experimental0.001
Research integrity0.001
Meta-analysis0.000
Theoretical or conceptual0.000
Meta-epidemiology (broad)0.000
Non-randomized trial0.000
Randomized trial0.000
Not applicable0.000
Other design0.000
Open science0.000
Systematic review0.000
Bibliometrics0.000
Scholarly communication0.000
Case report0.000
Meta-epidemiology (narrow)0.000
Qualitative0.000

Gemma

Observational0.992
Bench or experimental0.009
Simulation or modelling0.005
Theoretical or conceptual0.005
Research integrity0.003
Metaresearch0.002
Randomized trial0.001
Meta-analysis0.000
Case report0.000
Non-randomized trial0.000
Open science0.000
Systematic review0.000
Qualitative0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Bibliometrics0.000
Science and technology studies0.000
Scholarly communication0.000
Not applicable0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.089
GPT teacher head0.371
Teacher spread
0.282 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA has emerged as an attractive diagnostic modality allowing broad-range pathogen detection, noninvasive sampling, and earlier diagnosis. However, little is known about its real-world clinical impact as used in routine practice.

We performed a retrospective cohort study of all patients for whom plasma mNGS (Karius test) was performed for all indications at 5 United States institutions over 1.5 years. Comprehensive records review w…

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