<i>Plasmodium falciparum</i> evades immunity of anopheline mosquitoes by interacting with a Pfs47 midgut receptor
Bibliographic record
Abstract
Significance The surface protein Pfs47 makes Plasmodium falciparum parasites “undetectable” to the mosquito immune system. We proposed the “lock and key” model in which a parasite expressing a compatible Pfs47 haplotype “the key,” is able to evade the mosquito immune system, by interacting with a mosquito Pfs47 receptor “the lock,” which differs between vectors from different continents. Here, we uncovered the identity of the mosquito midgut “Pfs47 receptor” (P47Rec). P47Rec has two natterin domains and structural homology to a cytoskeleton-interacting protein. It binds Pfs47 with high affinity, and silencing P47Rec reduced P. falciparum infection. The molecular interactions of P47Rec from different mosquito species with Pfs47 haplotypes from Africa and South America give further support to the lock and key model.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".