<i>Solanum macrocarpon</i> Leaf Extracts Reduced Blood Pressure and Heart Rate After Oral Administration to Spontaneously Hypertensive Rats
Bibliographic record
Abstract
The aim of this work was to determine the ability of polyphenol-enriched aqueous vegetable leaf extracts to ameliorate blood pressure and heart rate dysfunctions in spontaneously hypertensive rats (SHRs). Solanum macrocarpon (SM), a common edible vegetable leaf in West Africa was cultivated using varying levels (0-80 kg/ha) of urea that was applied at planting (T1) or 2 weeks after planting (T2). In vitro analysis showed that total polyphenolic compounds varied from 489.87 ± 5.66 to 513.56 ± 1.42 mg gallic acid equivalent/g dry wt of extract. Rutin, caffeic acid and myricetin were the major polyphenols quantified in the extracts. All the extracts inhibited in vitro activities of renin and angiotensin converting enzyme to varying extents. Two extracts (SM40T1 and SM80T2) were orally administered to SHRs at 100 or 500 mg/kg body wt. Results showed that systolic blood pressure was reduced to a similar level by SM40T1 (10.8 mmHg) and SM80T2 (10.5 mmHg) for the 100 mg/kg body wt dose; the 500 mg/kg body wt dose produced similar values. Diastolic blood pressure and heart rate were also depressed by the two extracts with similar effects observed for both doses. We conclude that the leaf extracts could serve as potential ingredients to formulate antihypertensive functional foods and nutraceuticals.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".