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Record W3003314143 · doi:10.1101/2020.01.28.921544

Composition of the North American wood frog ( <i>Rana sylvatica</i> ) skin microbiome and seasonal variation in community structure

2020· preprint· en· W3003314143 on OpenAlexafffund
Alexander J. Douglas, Laura A. Hug, Barbara A. Katzenback

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2020
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGut microbiota and health
Canadian institutionsUniversity of Waterloo
FundersNatural Sciences and Engineering Research Council of CanadaUniversity of WaterlooUniversities Space Research Association
KeywordsMicrobiomeBiologyAmphibianEcologyBacteroidetesHost (biology)ProteobacteriaMicrobial population biologyZoologyActinobacteriaBacteria

Abstract

fetched live from OpenAlex

Abstract While a number of amphibian microbiomes have been characterized, it is unclear how microbial communities might vary in response to seasonal changes in the environment and the behaviors which many amphibians exhibit. Given recent studies demonstrating the importance of the skin microbiome in frog innate immune defenses against pathogens, investigating how changes in the environment impact the microbial species present, and thus their potential contribution to skin host defense, will provide a better understanding of conditions that may alter host susceptibility to pathogens in their environment. We sampled the skin microbiome of North American wood frogs ( Rana sylvatica ) from two breeding ponds in the spring, along with the microbial community present in their vernal breeding pools, and frogs from the nearby forest floor in the summer and fall to determine whether the microbial composition differs by sex, vernal pond site, or temporally across season (spring, summer, fall). Taxon abundance data reveals a profile of bacterial phyla similar to those previously described on anuran skin, with Proteobacteria, Bacteroidetes, and Actinobacteria dominating the wood frog skin microbiome. Our results indicate that sex had no significant effect on skin microbiota diversity, however, this may be due to our limited female sample size. Vernal pool site had a small but significant effect on skin microbiota, but skin-associated communities were more similar to each other than to the communities observed in the frogs’ respective pond water. Across seasons, diversity analyses suggest there are significant differences between the skin microbiome of frogs from spring and summer/fall groups while the average α-diversity per frog remained consistent. Bacterial genera known to have antifungal properties such as Pseudomonas spp. and Rhizobium spp. were prevalent, and several were considered core microbiota during at least one season. These results illustrate seasonal variation in wood frog skin microbiome structure and highlight the importance of considering temporal trends in an amphibian microbiome, particularly for species whose life history requires recurrent shifts in habitat and behavior.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.996
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.210
Teacher spread0.203 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2020
Admission routes2
Has abstractyes

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