Learning and memory in a rat model of social jetlag that also incorporates mealtime
Bibliographic record
Abstract
Given the increasing role of circadian rhythm disruption in health and disease, animal models are necessary to elucidate the mechanisms and effects involved. Social jetlag is a mild form of chronic circadian rhythm disruption that involves a misalignment between one’s internal time and their external schedule. Using phase advances and delays that are characteristic of a typical working week with sleep binging on the weekend, we propose an animal model of social jetlag. We also investigate the role of the food entrainable oscillator in learning and memory by manipulating the regularity and number of daily meals. We hypothesized that rats exposed to social jetlag would display cognitive impairments. It was unclear if a consistent meal would ameliorate the deleterious effects of social jetlag. Rats exposed to either social jetlag or unpredictable meals had impaired hippocampal-dependent memory. Activity data suggest that the social jetlag paradigm was unentrainable. Our social jetlag paradigm is a useful model of circadian misalignment that impairs cognition by rapidly uncoupling circadian rhythms from the environment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".