Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Abstract
In December 2019, a novel pneumonia caused by a previously \nunknown pathogen emerged in Wuhan, a city of 11 million \npeople in central China. The initial cases were linked to \nexposures in a seafood market in Wuhan.1 As of January 27, \n2020, the Chinese authorities reported 2835 confirmed cases in \nmainland China, including 81 deaths. Additionally, 19 confirmed \ncases were identified in Hong Kong, Macao and Taiwan, and 39 \nimported cases were identified in Thailand, Japan, South Korea, \nUnited States, Vietnam, Singapore, Nepal, France, Australia \nand Canada. The pathogen was soon identified as a novel \ncoronavirus (2019-nCoV), which is closely related to sever acute \nrespiratory syndrome CoV (SARS-CoV).2 Currently, there is no \nspecific treatment against the new virus. Therefore, identifying \neffective antiviral agents to combat the disease is urgently \nneeded.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Cell Research
- Topic
- SARS-CoV-2 and COVID-19 Research
- Field
- Medicine
- Canadian institutions
- —
- Funders
- Wuhan National Biosafety LaboratoryNational Natural Science Foundation of China
- Keywords
- LopinavirRibavirinFavipiravirVirologyChloroquineNitazoxanideAntiviral drugMiddle East respiratory syndrome coronavirusBiologyPneumoniaMiddle East respiratory syndromeCoronavirusBetacoronavirusMedicineImmunologyVirusCoronavirus disease 2019 (COVID-19)Viral loadInternal medicineDiseaseHepatitis C virusInfectious disease (medical specialty)Malaria
- Has abstract in OpenAlex
- yes