AB010. The effect of visual conditioning on cortical map plasticity: a wide-field calcium imaging study
Bibliographic record
Abstract
Background: Visual conditioning can refine the response of neurons in the visual cortex and higher visual and cognitive processing of a presented stimulus. This process results in increased sensitivity for that stimulus. The development of new optical imaging technology in the field of neuroscience has led to important advances, notably to better define the functional organization and plasticity of visual areas. The objective of this project is to determine the effect of daily visual conditioning with an oblique sinusoidal grating on the distribution and amplitude of cortical responses. For this, we use wide-field calcium imaging on awake mice, allowing for the observation of responses to a stimulus throughout the entire cortex in real time. Methods: C57BL/6 mice, expressing the GCaMP6s calcium reporter gene, are used to longitudinally measure neuronal activity via wide-field calcium imaging. Spontaneous activity at rest, as well as cortical responses to visual stimuli consisting of sinusoidal networks with orientation (0, 30°, 60° and 90°), spatial frequency (0.03, 0.12, 0.24 and 0.48 cpd) and contrast (100%, 75% and 50%) variables are recorded to establish cortical maps, as well as tuning curves. Subsequently, the baseline function of the cortex, as well as the cortical representation of visual stimulation (30° or 90°, 0.03 cpd and a contrast of 50%, 75% and 100%) are studied in the animal before, during, and after daily monocular conditioning, consisting of a specific sinusoidal network (30°, 0.03 cpd and 100%) over a period of 7 days. The variations in intensity and activation specificity of various visual cortical areas are calculated according to the visual conditioning and compared to an orientation stimulus for which the animal has not been conditioned (90°). Results: The cortical activation curves show a greater sensitivity of response for stimuli having horizontal or vertical gratings (0 and 90°) than for oblique gratings (30° and 60°) at low spatial frequencies (0, 0.3 and 0.12 cpd). However, this trend does not occur with high spatial frequencies (0.24 and 0.48 cpd). Finally, although the intensity of activation varies in a way that is not proportional to the contrast of the stimulation, it would have no influence on the perception of the orientation of the stimuli. Conditioning at a 30° stimulus results in greater activation of the primary visual cortex and some extra-striate visual areas, as well as greater amplification of the ipsilateral cortical responses to the presentation of the visual stimuli. Conclusions: In conclusion, the results demonstrate that visual conditioning would allow for plasticity and consolidation of higher visual pathways.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".