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Record W3008877371 · doi:10.1016/j.dld.2019.12.123

Overall Health, Daily Functioning, and Quality of Life in Acute Hepatic Porphyria Patients: ENVISION, a Phase 3 Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

2020· article· en· W3008877371 on OpenAlexaff
Eliane Sardh, Laurent Gouya, David C. Rees, Penelope E. Stein, U. Stölzel, D. Montgomery Bissell, Herbert L. Bonkovsky, Sioḃán Keel, Charles Parker, John D. Phillips, S. Silver, Jerzy Windyga, Delia D’Avola, Gayle Ross, Peter Stewart, Bruce Ritchie, Jeeyoung Oh, Pauline Harper, J.D. Wang, Janneke G. Langendonk, Aneta Ivanova, Yoshiharu Horie, Karl E. Anderson, Paolo Ventura, Raili Kauppinen, Daphne Vassiliou, B. Wang, Ole Hother‐Nielsen, T. Nakahara, M.J. Lee, Appalanaidu Sasapu, Sushama Scalera, Tim Lin, Craig Penz, Amy Simon, John J. Ko, Manisha Balwani

Bibliographic record

VenueDigestive and Liver Disease · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPorphyrin Metabolism and Disorders
Canadian institutionsUniversity of Alberta HospitalAlberta Hospital Edmonton
Fundersnot available
KeywordsMedicinePorphyriaQuality of life (healthcare)Porphobilinogen synthasePlaceboHemeDiseaseRandomized controlled trialLiver enzymeInternal medicineEnzymeDehydratasePathologyBiochemistryAlternative medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.013
Threshold uncertainty score0.793

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.300
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2020
Admission routes1
Has abstractno

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