Intravascular large B-cell lymphoma of the central nervous system, a masquerader on radiography and clinical presentation: A case report
Bibliographic record
Abstract
A 72-year-old woman presented to the emergency department with progressive left hemiparesis, confusion, urinary incontinence and frequency. She was hospitalized multiple times during the last 6 months for stroke work-up and seizure management necessitating intubation and ICU admission. An MRI done at that time revealed multiple foci of abnormal diffusion restriction in both cerebral hemispheres. Further vasculitis work-up was positive for ANA and RNP A and the patient was started on high dose prednisone therapy without significant improvement. A CT with contrast done during the latest admission showed a hyper-dense enhancing nodule in the right frontal lobe suggestive of metastasis. She underwent a right-sided frontal image guided needle biopsy. The pathology was consistent with intravascular large B cell lymphoma (IVLBCL). IVLBCL limited to the central nervous system (CNS) is extremely rare [1], with only few cases reported in the literature [2]. It is usually misdiagnosed as cerebral infarction on radiology and clinical presentation. Definite diagnosis necessitates tissue biopsy. Hereby we present the 9th case of biopsy proven IVLBCL limited to the CNS mimicking cerebral infarction and inflammatory conditions on radiography and by clinical presentation
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".