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Record W3010014305 · doi:10.1128/jmbe.v21i1.2005

Facilitating Growth through Frustration: Using Genomics Research in a Course-Based Undergraduate Research Experience

2020· article· en· W3010014305 on OpenAlexaff
David Lopatto, Anne Rosenwald, Justin R. DiAngelo, Amy T. Hark, Matthew P. Skerritt, Matthew Wawersik, Anna K. Allen, Consuelo J. Alvarez, Sara Anderson, Cindy Arrigo, Andrew M. Arsham, Daron Barnard, Christopher Bazinet, James E. J. Bedard, Indrani Bose, John M. Braverman, Martin G. Burg, Rebecca C. Burgess, Paula Croonquist, Chunguang Du, Sondra Dubowsky, Heather Eisler, Matthew A. Escobar, Michael S. Foulk, Emily C. Furbee, Thomas C. Giarla, Rivka L. Glaser, Anya Goodman, Yuying Gosser, Adam Haberman, Charles R. Hauser, Shan Hays, Carina E. Howell, Jennifer C. Jemc, M. Logan Johnson, Christopher J. Jones, Lisa Kadlec, Jacob D. Kagey, Kimberly L. Keller, Jennifer A. Kennell, S. Catherine Silver Key, Adam J. Kleinschmit, Melissa Kleinschmit, Nighat P. Kokan, Olga R. Kopp, Meg M. Laakso, Judith L. Leatherman, Lindsey J Long, Mollie K. Manier, Juan Carlos Martínez‐Cruzado, Luis F. Matos, Amie J. McClellan, Gerard P. McNeil, Evan Merkhofer, Vida Mingo, Hemlata Mistry, Elizabeth Mitchell, Nathan T. Mortimer, Debaditya Mukhopadhyay, Jennifer Leigh Myka, Alexis Nagengast, Paul Overvoorde, Don Paetkau, Leocadia V. Paliulis, Susan Parrish, Mary L. Preuss, James V. Price, Nick Pullen, Catherine Reinke, Dennis Revie, Srebrenka Robic, Jennifer Roecklein‐Canfield, Michael R. Rubin, Takrima Sadikot, Jamie Siders Sanford, Maria Santisteban, Kenneth Saville, Stephanie Schroeder, C. Shaffer, Karim A. Sharif, Diane E. Sklensky, Chiyedza Small, Mary Ann Smith, Sheryl T. Smith, Rebecca Spokony, Aparna Sreenivasan, Joyce Stamm, Rachel Sterne‐Marr, Katherine C. Teeter, Justin Thackeray, Jeffrey S. Thompson, Stephanie Toering Peters, Melanie Van Stry, Norma Velazquez-Ulloa, Cindy Wolfe, James J Youngblom, Brian C. Yowler, Leming Zhou, Janie Brennan, Jeremy Buhler, Wilson Leung, Laura K Reed, Sarah C. R. Elgin

Bibliographic record

VenueJournal of Microbiology and Biology Education · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Bioinformatics, and Biomedical Research
Canadian institutionsUniversity of the Fraser Valley
FundersNational Institute of General Medical Sciences
KeywordsFormative assessmentFrustrationGeneral partnershipProcess (computing)Computer scienceGenomicsSet (abstract data type)Data scienceAnnotationMathematics educationPsychologyMedical educationGenomeArtificial intelligenceMedicineBiologySocial psychologyGeneticsGene

Abstract

fetched live from OpenAlex

A hallmark of the research experience is encountering difficulty and working through those challenges to achieve success. This ability is essential to being a successful scientist, but replicating such challenges in a teaching setting can be difficult. The Genomics Education Partnership (GEP) is a consortium of faculty who engage their students in a genomics Course-Based Undergraduate Research Experience (CURE). Students participate in genome annotation, generating gene models using multiple lines of experimental evidence. Our observations suggested that the students' learning experience is continuous and recursive, frequently beginning with frustration but eventually leading to success as they come up with defendable gene models. In order to explore our "formative frustration" hypothesis, we gathered data from faculty via a survey, and from students via both a general survey and a set of student focus groups. Upon analyzing these data, we found that all three datasets mentioned frustration and struggle, as well as learning and better understanding of the scientific process. Bioinformatics projects are particularly well suited to the process of iteration and refinement because iterations can be performed quickly and are inexpensive in both time and money. Based on these findings, we suggest that a dynamic of "formative frustration" is an important aspect for a successful CURE.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.019
metaresearch head score (Gemma)0.048
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.019
Threshold uncertainty score0.099

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0190.048
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0070.007
Scholarly communication0.0100.006
Open science0.0020.013
Research integrity0.0020.004
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.147
GPT teacher head0.434
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations38
Published2020
Admission routes1
Has abstractyes

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