The suppression effects of Ratanasampil on oxidative stress-induced neuronal damage and microglia-mediated neuroinflammation
Bibliographic record
Abstract
Generation of reactive oxygen species (ROS) causes lipids, proteins and DNA damage, resulting in neuronal damage and neruoinflammation. Ratanasampil (RNSP), a traditional Tibetan medicine, clinically used for the mild-to moderate AD patients living at high altitude. In vivo, RNSP improved the learning and memory in an AD mouse model (Tg2576). However, mechanism underlying the effects of RNSP is unknown. In SH-SY5Y cells, RNSP significantly ameliorated the H2O2 –induced cytotoxicity. Furthermore, RNSP significantly reduced the H2O2-induced 8-oxo-2′-deoxyguanosine and attenuated the phosphorylation of p38 and ERK 1/2. In MG6 microglia, RNSP significantly ameliorated the cytotoxicity induced by hypoxia-reoxygenation. Furthermore, RNSP significantly suppressed the H6/R24-induced pro-inflammatory cytokines, ROS, DNA damage and phosphorylation of IκBα. These observations suggest that RNSP suppressed the H2O2-induced neuronal death through downregulation of p38-ERK activation and regulated the H/R-induced neuroinflammation through inhibition of oxidative stress and the activation of NFκB in MG6 cells. Therefore, RNSP may be beneficial for preventing oxidative stress-induced neuronal death and neuroinflammation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".