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Record W3012803438 · doi:10.1249/mss.0000000000002343

A “Step–Ramp–Step” Protocol to Identify the Maximal Metabolic Steady State

2020· article· en· W3012803438 on OpenAlexafffund
Danilo Iannetta, Erin Calaine Inglis, Silvia Pogliaghi, Juan M. Murias, Daniel A. Keir

Bibliographic record

VenueMedicine & Science in Sports & Exercise · 2020
Typearticle
Languageen
FieldMedicine
TopicCardiovascular and exercise physiology
Canadian institutionsUniversity Health NetworkUniversity of Calgary
FundersCanadian Institutes of Health Research
KeywordsRespiratory compensationExtrapolationSteady state (chemistry)Linear regressionLactate thresholdMathematicsCyclingChemistryAnimal scienceAnaerobic exerciseStatisticsBlood lactateMedicinePhysical therapyInternal medicineHeart ratePhysical chemistry

Abstract

fetched live from OpenAlex

The oxygen uptake (V[Combining Dot Above]O2) at the respiratory compensation point (RCP) closely identifies with the maximal metabolic steady state. However, the power output (PO) at RCP cannot be determined from contemporary ramp-incremental exercise protocols. PURPOSE: This study aimed to test the efficacy of a "step-ramp-step" (SRS) cycling protocol for estimating the PO at RCP and the validity of RCP as a maximal metabolic steady-state surrogate. METHODS: Ten heathy volunteers (5 women; age: 30 ± 7 yr; V[Combining Dot Above]O2max: 54 ± 6 mL·kg·min) performed in the following series: a moderate step transition to 100 W (MOD), ramp (30 W·min), and after 30 min of recovery, step transition to ~50% POpeak (HVY). Ventilatory and gas exchange data from the ramp were used to identify the V[Combining Dot Above]O2 at lactate threshold (LT) and RCP. The PO at LT was determined by the linear regression of the V[Combining Dot Above]O2 versus PO relationship after adjusting ramp data by the difference between the ramp PO at the steady-state V[Combining Dot Above]O2 from MOD and 100 W. Linear regression between the V[Combining Dot Above]O2-PO values associated with LT and HVY provided, by extrapolation, the PO at RCP. Participants then performed 30-min constant-power tests at the SRS-estimated RCP and 5% above this PO. RESULTS: All participants completed 30 min of constant-power exercise at the SRS-estimated RCP achieving steady-state V[Combining Dot Above]O2 of 3176 ± 595 mL·min that was not different (P = 0.80) from the ramp-identified RCP (3095 ± 570 mL·min) and highly consistent within participants (bias = -26 mL·min, r = 0.97, coefficient of variation = 2.3% ± 2.8%). At 5% above the SRS-estimated RCP, four participants could not complete 30 min and all, but two exhibited non-steady-state responses in blood lactate and V[Combining Dot Above]O2. CONCLUSIONS: In healthy individuals cycling at their preferred cadence, the SRS protocol and the RCP are capable of accurately predicting the PO associated with maximal metabolic steady state.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.825
Threshold uncertainty score0.972

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.003
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.329
Teacher spread0.304 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations81
Published2020
Admission routes2
Has abstractyes

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