15-Epi-LXA <sub>4</sub> and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation
Bibliographic record
Abstract
Significance Timely resolution of bacterial infections critically depends on phagocytosis of invading pathogens by polymorphonuclear neutrophil granulocytes, followed by neutrophil apoptosis and removal by macrophages. Neutrophils integrate cues from the inflammatory microenvironment. Here we show a Toll-like receptor 9-mediated mechanism, involving regulation of phagocytosis and phagocytosis-induced neutrophil apoptosis, by which bacterial DNA, a pathogen-associated molecular pattern, and the danger signal mitochondrial DNA may impair host defense to bacteria and prolong the inflammatory response. We also report that the proresolution aspirin-triggered lipids 15-epi-lipoxin A 4 and 17-epi-resolvin D1 restore impaired phagocytosis and enhance bacterial clearance and phagocytosis-induced neutrophil apoptosis, thereby facilitating resolution of acute lung inflammation. These findings imply the lipoxin receptor ALX/FPR2 as a potential therapeutic target for combating bacterial infections.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".