Singlet Oxygen Luminescence Image in Blood Vessels During Vascular‐Targeted Photodynamic Therapy
Bibliographic record
Abstract
Abstract Singlet oxygen (1O2) is widely regarded as the main cytotoxic substance that induces the biological damage for photodynamic therapy (PDT). In this study, the previously developed near‐infrared (NIR) optical imaging system was optimized for fast imaging of 1O2 luminescence. The optical imaging system enables direct imaging of 1O2 luminescence in blood vessels within 2 s during vascular‐targeted PDT (V‐PDT), which makes this system extremely practical for in vivo studies. The dependence of RB concentration on 1O2 luminescence image was investigated for V‐PDT, and the data imply that 1270 nm signal is attributed to 1O2 luminescence. The imaging system operates with a field of view of 9.60 × 7.68 mm2 and a spatial resolution of 30 μm, which holds the potential to elucidate the correlation between cumulative 1O2 luminescence and vasoconstriction for V‐PDT.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".