Tremolite–actinolite fiber coatings of sub-nanometer silica-rich particles in lungs from deceased Quebec miners
Bibliographic record
Abstract
Tremolite–actinolite (TA) fibers from the lungs of deceased former Quebec mine workers were found to be coated with sub-nanometer particles. Qualitative chemical analyses were performed on the particles indicating that they were composed of silicon and oxygen. The crystal lattice structure of all amphibole minerals, including the TA series, is arranged as pairs of linear chains of SiO 4 tetrahedra that are linked together to form double chains. Our observations of the TA fibers from miner’s lungs, made using a high-resolution transmission electron microscope, indicated that the tetrahedral silica chains were progressively split, forming dispersed sub-nanometer particles. The non-tetrahedral sites were removed at the surface of the TA fibers, presumably by the oxidation process involved in attempted phagocytosis, which also resulted in fragmentation of the tetrahedral chains. It was found that the silicon-rich particles (SRPs) were variable in diameter, consistent with fragments formed from the splitting of the tetrahedral chains. The TA fibers from lungs displayed coatings and linear interior zones of SRP parallel to the planes of longitudinal fiber splitting. The literature on very small nanoparticles is consistent with deep penetration of SRP into cell DNA interiors, oxidative stress, and carcinogenesis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".