Effect of Asparagus racemosus on selected female reproductive parameters using Wistar rat model.
Why this work is in the frame
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Bibliographic record
Abstract
Dysmenorrhea is a major cause of female morbidity globally. Asparagus racemosus (ASP) is traditionally used to manage dysmenorrhea in Nakuru, Kenya. This study evaluates the effect of Asparagus racemosus on female reproductive parameters; estrus cyclicity, mating success, gestation length, litter size and dysmenorrhea. The effect of Asparagus racemosus and ibuprofen on isolated uterine strips was evaluated using six non-pregnant rats. The uterine strips were exposed to serial extract concentrations (20, 40, 80,160 mg/ml) and 20 mg/ml ibuprofen was used as a positive control.There was significant increase of proestrus phase (P < 0.001) and a subsequent significant reduction in the metestrus (P < 0.01) and diestrus (P < 0.05). No significant difference in mating success and gestation length, however Ibuprofen caused significant disruption of gestation length (P < 0.05). Â The treated groups produced higher number of pups compared to controls. The plant extract caused a dose dependent significant reduction in uterine force of contraction by (-0.15%, -5.13%, -7.97%, -19.55 %) at 20, 40, 80 and 160 mg/ml respectively. The plant extract also caused a significant decline in frequency of uterine contraction (-5.99%; -9.61%; -16.76% and -25.21%) The extract caused no mortality even at the limit dose; 5000 mg/kg. Asparagus racemosus reduces uterine force and frequency of contraction. This is probably the reason for its traditional use in dysmenorrhea management.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it