SUN-630 Insulin Pumps Versus Multiple Daily Injections in Type 1 Diabetic Pregnancies
Bibliographic record
Abstract
Abstract Background: Pregnancy is associated with physiological increased resistance to insulin, leading to increased insulin requirements for diabetic women. Poor glycemic control in pregnancy is associated with neonatal and maternal complications. Insulin has been traditionally administered subcutaneously through multi daily injections (MDIs) however, use of insulin pumps or continuous subcutaneous insulin infusion (CSII) has become more widespread. As glycemic control has direct influence on perinatal and maternal outcomes, comparing MDIs and CSII in pregnant women with Type 1 Diabetes Mellitus (DM1) is of interest. Aim: To investigate whether there is a difference in birth weights in infants born from DM1 mothers who use CSII compared to MDIs. Methods and Results: This is a retrospective cohort study of women diagnosed with DM1 on either MDIs or CSII whose pregnancies were followed at our institution. The following data was collected on chart review: age, years since DM1 diagnosis, BMI and weight gain at each trimester, total daily insulin dose at delivery, presence of retinopathy or nephropathy, gestational age at delivery, delivery method, presence of hypertension, pre-eclampsia or eclampsia, birth weight, sex of infant and neonatal complications. Preliminary analysis of our currently available data demonstrates that in age-matched groups of women on MDI (N=44) compared to CSII (N=8), there was no significant difference in infant birth weights (3491g ± 760 vs. 3554g ± 666, respectively). There was also no significant difference in neonatal complications (jaundice, hypoglycemia, shoulder dystocia, macrosomia, respiratory distress or prematurity). Women on CSII had been diagnosed with DMI for a significantly longer period of time (20 vs. 14 years) and were on higher total daily doses of insulin per body weight at time of delivery (p<0.05). Despite this, there was no significant difference in weight gain during pregnancy between the groups. There was also no significant difference in the presence of hypertension, pre-eclampsia, eclampsia or in C-section rates. Discussion: Given the paucity of studies and the increasing use of pump technology among diabetic women, there remains a need for further research comparing the effects of MDIs and pumps on birthweights as well as other neonatal and maternal outcomes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".