MétaCan
Menu
Back to cohort
Record W3025838847 · doi:10.1038/s41593-020-0628-4

RETRACTED ARTICLE: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma

2020· article· en· W3025838847 on OpenAlexafffund
Alexandra Garancher, Hiromichi Suzuki, Svasti Haricharan, Lianne Q. Chau, Meher Beigi Masihi, Jessica M. Rusert, Paula S. Norris, Florent Carrette, Megan M. Romero, A. Sorana Morrissy, Patryk Skowron, Florence M.G. Cavalli, Hamza Farooq, Vijay Ramaswamy, Steven J.M. Jones, Richard A. Moore, Andrew J. Mungall, Yussanne Ma, Nina Thiessen, Yisu Li, Alaide Morcavallo, Lin Qi, Mari Kogiso, Yuchen Du, Patricia Baxter, Jacob J. Henderson, John R. Crawford, Michael L. Levy, James M. Olson, Yoon-Jae Cho, Aniruddha J. Deshpande, Xiao‐Nan Li, Louis Chesler, Marco A. Marra, Harald Wajant, Oren J. Becher, Linda M. Bradley, Carl F. Ware, Michael D. Taylor, Robert J. Wechsler‐Reya

Post-publication record

NatureRetraction
ReasonResults Not Reproducible;Unreliable Data;Unreliable Results and/or Conclusions;
Date12/14/2021 0:00
Flagged by OpenAlex?Yes

Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement; it reports them as false, which reads as “fine”.

Bibliographic record

VenueNature Neuroscience · 2020
Typearticle
Languageen
FieldMedicine
TopicCancer Immunotherapy and Biomarkers
Canadian institutionsUniversity of CalgaryCanada's Michael Smith Genome Sciences CentreHospital for Sick Children
FundersNational Cancer InstituteCanadian Institutes of Health ResearchU.S. Department of Health and Human ServicesCenter for Scientific ReviewAmerican Brain Tumor AssociationStand Up To CancerCalifornia Dental Association FoundationBrain Tumour CharitySparksNational Institute of Allergy and Infectious DiseasesMedical Research CouncilCureSearch for Children's CancerCancer Research UKAccelerate Brain Cancer CureMassachusetts Department of Fish and GameV Foundation for Cancer ResearchDeutsche ForschungsgemeinschaftGovernment of CanadaAlex's Lemonade Stand Foundation for Childhood CancerDivision of Cancer Epidemiology and Genetics, National Cancer InstituteSt. Baldrick's FoundationCalifornia Institute for Regenerative MedicinePediatric Cancer Research FoundationNational Institutes of Health
KeywordsMajor histocompatibility complexTumor necrosis factor alphaCytotoxic T cellMHC class IImmune systemBiologyCancer researchImmunotherapyImmunologyImmune checkpointIn vitro

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.015
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesResearch integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.988
Threshold uncertainty score0.030

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.015
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.001
Science and technology studies0.0020.002
Scholarly communication0.0020.002
Open science0.0040.001
Research integrity0.0120.010
Insufficient payload (model declined to judge)0.0080.005

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.279
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations41
Published2020
Admission routes2
Has abstractno

Explore more

Same venueNature NeuroscienceSame topicCancer Immunotherapy and BiomarkersFrench-language works237,207