Abstract TMP109: Cortico-Ponto-Cerebellar Structural Connectivity in Perinatal Stroke
Bibliographic record
Abstract
Introduction: Perinatal stroke (PS) causes hemiparetic cerebral palsy and lifelong disability. As an early cerebrovascular injury, typically involving injury to motor systems, PS represents an ideal model for understanding motor system development. Emerging models demonstrate widespread network alterations but the role of the cerebellum is poorly defined. We used diffusion tractography to explore the development of the cortico-ponto-cerebellar (CPC) tract in children with PS, hypothesizing an association between non-dominant CPC diffusion metrics and motor ability. Methods: Retrospective, population-based, cross-sectional, controlled study. Participants aged 6-19 years with unilateral MRI confirmed perinatal arterial ischemic stroke (AIS; n=11) or periventricular venous infarction (PVI; n=20), and typically developing controls (TDC; n=31) had a 3T MRI including T1-weighted and diffusion imaging (32 directions; b=750s/mm 2 , 3 b0 volumes). Probabilistic tensor-based tractography was performed using the posterior limb of the internal capsule and contralateral middle cerebellar peduncle as regions of interest for seeding. Tensor-based outcomes were calculated including mean diffusivity (MD) and fractional anisotropy (FA). An asymmetry index (AI) was subsequently calculated (dominant / non-dominant values). PS participants completed motor assessments [Assisting Hand Assessment (AHA), Melbourne Assessment (MA), Box and Blocks Test (BBT)]. Results: Paired-samples t-tests revealed MD was significantly higher for non-dominant versus dominant tracts across all groups (all p<0.001), while FA did not differ (all p>0.05). MD AI differed among groups (F(2,59)=10.117, p <0.001) such that MD AI was significantly lower (less symmetrical) in AIS (AI=0.912±0.04) compared to PVI (AI=0.960±0.05, p =0.01) and TDC (AI=0.977±0.03, p <0.001). FA AI did not differ between groups (F(2,59)=1.045, p =0.358). A positive association was observed between MD AI and BBT performance in the affected hand (r=0.439, p =0.019). Conclusion: CPC tractography in children with PS is feasible. Development of the CPC appears to be altered following perinatal stroke, the degree of which may relate to motor function.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".