Atractylodes Rhizome and Taraxacum Alleviate Colorectal Damage and Inflammation on DSS‐Induced Colitis in Mice
Bibliographic record
Abstract
Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are common chronic disorder of the gastrointestinal tract with a high prevalence rate worldwide. According to the Korean traditional pharmacopeia (Donguibogam), atractylodes rhizomes is among the most common ingredient to combine with taraxacum to treat intestinal dysfunction, providing a rationale to investigate the effect using modern technologies. In this study, we aimed to examine the effect of a combination of atractylodes rhizomes/taraxacum (AT) on maintaining gut health in by targeting the mucosal immunoinflammatory response in DSS‐induced colitis mice. Female Balb/c mice (7 weeks old, n =20) were randomly divided into four groups; normal control group (NC), DSS‐treated positive control group (DSS), AT treated group (A), and DSS + AT treated group (DA). AT (100 mg/kg/day) or placebo was administered by gavage for 14 days. For induction of acute colitis, mice received 3% of DSS dissolved in drinking water for last 7 days. Epithelial barrier permeability was significantly improved by AT administration, as measured by fluorescein isothiocyanate labeled dextran at the end of experimental period. Body weight, colon length, and disease activity index were significantly restored toward normal in the DA group compared to the DSS group. Histological analysis demonstrated that AT administration reduced cell destruction and inflammation of colon tissue. In parallel with these results, quantitative real‐time PCR analysis revealed that AT administration down‐regulated gene expression related to pro‐inflammatory activation (TNF‐α, IFN‐γ, IL‐1β, IL‐6, and COX‐2) compared with that in the DSS group. Further analysis of target gene expression related to cell proliferation/destruction, and mucin secretion is now on‐going. These results suggest that AT alleviates gut permeability, colon tissue destruction, and pro‐inflammation that was induced upon DSS stimulation. Support or Funding Information This work was supported by the Bio‐Synergy Research Project (NRF‐2012M3A9C4048761) of the Ministry of Science, ICT and Future Planning, and the BK21PLUS program (22a20130012143P of the Ministry of Education.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".