Effects of hyperbaric oxygen combined with Oxiracetam on cognitive function and related cytokines in patients after brain trauma
Bibliographic record
Abstract
Objective To investigate the effect of hyperbaric oxygen combined with Oxiracetam on cognitive function and related cytokines in patients with post-traumatic cognitive impairment. Methods Sixty patients with post-traumatic cognitive impairment hospitalized from January 2017 to October 2018 in neurosurgery department of Xuzhou Central Hospital were randomly divided into control group and treatment group, 30 cases in each group. The control group received conventional routine treatment, and the treatment group was treated with hyperbaric oxygen combined with Oxiracetam on the basis of routine treatment. The course of treatment is 3 weeks. The concentration of angiopoietin-1 (Ang-1), brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) were measured, and the Chinese version of the Monterey’s cognitive-score scale (MOCA) was used to evaluate the cognitive functions before treatment and 3 weeks after treatment. Results Before treatment there was no significant difference in the levels of Ang-1, VEGF and BDNF between the two groups (P>0.05). After 3 weeks of treatment, the serum levels of Ang-1, VEGF and BDNF in the two groups increased. The levels of serum Ang-1, VEGF and BDNF in the treatment group were significantly higher than that in the control group, and the difference was statistically significant (P 0.05). After 3 weeks of treatment, the MOCA score of the treatment group was higher than that of the control group (P<0.05), and the difference was statistically significant. Conclusion Compared with conventional therapy, hyperbaric oxygen combined with oxiracetam can promote the secretion of Ang-1, VEGF and BDNF in patients with post-traumatic cognitive impairment, thus improving the cognitive function of patients with post-traumatic cognitive impairment. Key words: Post-traumatic cognitive impairment; Angiopoietin-1; Vascular endothelial growth factor; Brain-derived neurotrophic factor; Hyperbaric oxygen; Oxiracetam
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".