Language task-based functional connectivity in patients with post-stroke expressive aphasia: a preliminary fMRI study
Bibliographic record
Abstract
Objective To evaluate the functional connectivity through verbal association tasks in patients with post-stroke expressive aphasia,and to explore variation and neural mechanism of functional connectivity on language task-related brain region after expressive aphasia.Methods Ten patients with expressive aphasia after cerebral infarction [all males,aged 43 to 77,mean age (56.7±8.6) years old] and 10 normal volunteers (all males,age 46 to 74,average age 56.2±9.0) underwent data collection with functional magnetic resonance imaging (fMRI) during verbal association task.SPM2,AFNI and Matlab softwares were applied in pre-processing and statistical analysis of the data.Based on the activation results of the normal group,the active region of left posterior inferior frontal gyms was selected as the seed region of functional connectivity with a central Montreal Neurological Institute (MNI) coordinate of -51,9,21,and analyzed along with time series of other voxels within whole brain.Intra-and inter-group analyses were performed with single sample and two sample t-tests.The statistical threshold was voxel ＞ 30.P ＜ 0.001 (uncorrected) was considered as significant.Results Brain regions showed positive correlation with the seed region in control group,which mainly included the left inferior frontal gyms,left middle frontal gyms,insula,left precuneus,inferior parietal lobule,left middle temporal gyms,left basal ganglia,left thalamus,right inferior frontal gyms,right middle frontal gyms,right insula,right inferior temporal gyms,right superior temporal gyms,supplemental motor areas (SMA) and right inferior parietal lobule.Brain regions showed positive correlation with the seed point in patient group,which mainly included the posterior part of the left inferior frontal gyms,left insula,left posterior central gyms and left inferior parietal lobule.The brain regions with greater correlation to seed point in control group compared to patient group included right middle temporal gyms,right superior temporal gyms and right inferior frontal gyms.The brain regions with greater correlation to seed point in patient group compared to control group included left insula and left inferior frontal gyms.Conclusion Losing functional connectivity between the posterior part of the left inferior frontal gyrus and the regions in the right hemisphere is a neural mechanism for development of motor aphasia.The left perisylvian regions are significant for maintaining language function at the early phase of aphasia. Key words: Brain infarction; Aphasia, broca; Magnetic resonance imaging; Verbal association; Functional connectivity
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".