Effects of hyperbaric oxygen combined with memantine hydrochloride in the treatment of Alzheimer's disease
Bibliographic record
Abstract
Objective To explore the effects of hyperbaric oxygen (HBO) combined with memantine hydrochloride in the treatment of Alzheimer's disease and its impact on the levels of serum SOD and NSE. Methods Eighty-eight patients with Alzheimer's disease admitted to our hospital from June 2015 to June 2018 were selected as the study subjects. The patients were divided into the combined group and the control group, in accordance with different treatment methods. The control group was treated with memantine hydrochloride, while the combined group was treated with HBO coupled with memantine hydrochloride. After 8 weeks of treatment, the clinical effects were compared between the patients of the 2 groups. Mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) were used to assess the cognitive status of the patients. The changes of serum SOD and NSE levels were compared and adverse reactions of the 2 groups were analyzed for the patients of the 2 groups. Results The total effective rate of the combined group (84.09%) was obviously higher than that of the control group (63.64%) (χ2 = 4.768, P=0.029). After treatment, the scores of MMSE and MoCA in the combined group were (21.42 ±1.15) and (25.46±1.39) respectively, while those in the control group were (18.37 ±1.05) and (22.31±1.22) respectively (all P<0.05). Following treatment, the serum SOD levels of the 2 groups all increased, and the serum NSE level decreased (P<0.05). No significant significance could be noticed in the rate of adverse reactions, when comparisons were made between the 2 groups (χ2=0.067, P=0.769). Conclusion HBO combined with memantine hydrochloride in the treatment of Alzheimer's disease has good clinical efficacy, and could significantly improve the cognitive function of the patients, and increase serum SOD level, reduce NSE level and alleviate oxidative stress injury in the patients. Key words: Hyperbaric oxygen; Memantine hydrochloride; Alzheimer's disease; Superoxide dismutase; Neuron-specific enolase
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".