Clinical effect of hyperbaric oxygen combined with transcranial electrical stimulation and memantine hydrochloride on cognitive impairment in the patients with craniocerebral injury
Bibliographic record
Abstract
Objective To investigate the clinical efficacy of hyperbaric oxygen (HBO) combined with transcranial electrical stimulation (tDCS) and memantine tablets on cognitive impairment in the patients with moderate to severe craniocerebral injury. Methods Forty-nine patients with moderate or severe cognitive impairment induced by trauma brain injury (TBI) who were admitted into the Rehabilitation Department and Neurosurgery Department of Shanxi University Hospital from May 2017 to May 2018 were enrolled for the study. The patients were divided into the HBO group (or group A, n= 16), the HBO + tDCS group (or group B, n=16) and the HBO + tDCS + memantine group (or group C, n= 17) in accordance with different treatment methods. The total scores of Montreal Cognitive Assessment Scale (MoCA) and the scores of each item before and 4 weeks after treatment, the Simple Mental State Examination Scale (MMSE) and Barthel Index (BI) were analyzed to determine improvement of cognitive impairment in the TBI patients. Results After 3 courses of treatment, MoCA comprehensive scores and sub-item scores were all significantly higher than those before treatment, with statistical significance (P<0.01). In sub-items, the comprehensive scores of VS-EF, ATT, LANG, D-MEM and MoCA in group B were significantly higher than those in group A after treatment, also with statistical significance (P<0.05). Following treatment, the scores of VS-EF, ATT, LANG and D-MEM in group C were all significantly higher than those in group B after treatment, also with statistical significance (P<0.05). The comprehensive scores of MMSE and ADL in group B and C after treatment were all significantly higher than those in group A, and statistical significance could be seen when comparisons were made between them (P<0.01). The comprehensive scores of MMSE(21.23±6.53) and ADL(64.38±12.80) in group C were all obviously higher than those in group B(17.61±6.35, 5.39±10.22), also with statistical significance (P<0.05). Conclusion Comprehensive treatment with HBO+ tDCS+ memantine could achieve obvious better therapeutic effects on cognitive impairment of the patients with severe TBI. For this reason, it is worth further clinical application. Key words: Hyperbaric oxygen; Craniocerebral injury; Cognitive impairment; Transcranial electrical stimulation; Hydrochloric acid memantine
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".