Interhemispheric synchrony differences between multiple system atrophy (Parkinsonian type) and Parkinson′s disease
Bibliographic record
Abstract
Objective To investigate the resting-state functional connectivity of the two hemispheres between multiple system atrophy (Parkinsonian type, MSA-P) and Parkinson′s disease (PD). Methods A total of 25 MSA-P, 29 PD patients and 29 well-matched healthy controls recruited in the Nanjing Brain Hospital Affiliated to Nanjing Medical University from June 2013 to December 2015 were scanned with resting-state functional magnetic resonance imaging for voxel mirrored homotopic correlation (VMHC) analysis. The Mini Mental State Examination, Montreal Cognitive Assessment, Frontal Assessment Battery and Unified Parkinson′s Disease Rating Scale-Ⅲ (UPDRS-Ⅲ) were used to assess the clinical symptom. Then the relationship between the change of VMHC values and severity of clinical symptoms was investigated. Results Compared with healthy controls, MSA-P and PD patients both showed decreased VMHC in bilateral cerebellum posterior lobe, precuneus gyrus, middle temporal gyrus, and postcentral gyrus. Compared with PD or healthy controls, MSA-P patients exhibited lower VMHC in bilateral putamen. Significant negative correlation between VMHC values of putamen and UPDRS-Ⅲ scores was found in MSA-P patients (r=-0.607, P=0.001). Conclusion These functional changes suggest that the abnormal interhemispheric synchrony probably plays an important role in pathophysiology of both MSA-P and PD, and abnormal VMHC values in putamen of MSA-P may be helpful in differentiating MSA-P from PD. Key words: Multiple system atrophy; Parkinson disease; Magnetic resonance imaging; Voxel mirrored homotopic correlation
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".