Serum level changes in Toll-like receptor 2, 4 and soluble ST2 protein in the circulation in elderly patients with old myocardial infarction
Bibliographic record
Abstract
Objective To study the serum level changes in Toll-like receptor 2, 4 and soluble ST2 in the circulation in elderly patients with old myocardial infarction and the clinical significance. Methods A total of 140 patients with old myocardial infarction combined with chronic left-sided heart failure from Jan. 2010 to Mar. 2014, and 50 controls were selected. Serum level changes in TLR2 and TLR4 were detected by flow cytometry and compared with hs-CRP. The levels of hs-CRP and sST2 were tested by nephelometry immunoassay and enzyme-linked immunosorbent assay (ELISA) respectively. Results The levels of hs-CRP, TLR2, TLR4 and sST2 were elevated along with the severity of old myocardial infarction in elderly patients. The levels of hs-CRP, TLR2, TLR4 and sST2 were lower in patients with single vessel disease than in patients with four-vessel disease〔hs-CRP: (1.9±0.9) mg/L vs. (14.9±1.9) mg/L, TLR2: (7.5±0.9) MFI vs. (15.1±1.8) MFI, TLR4: (5.5±0.8) MFI vs. (11.8±7.1) MFI, sST2: (22.6±0.4)μg/L vs. (28.7±0.9)μg/L, all P<0.01〕. Levels of hs-CRP, TLR2, TLR4 and sST2 were lower in patients with NYHAⅠthan in patients with NYHA Ⅳ〔hs-CRP: (1.9±0.2) mg/L vs. (15.0±1.9) mg/L, TLR2: (7.3±0.2) MFI vs. (16.7±2.9)MFI, TLR4: (5.8±0.9) MFI vs. (17.9±6.9) MFI, sST2: (22.4±0.6) μg/L vs. (30.3±1.0) μg/L, all P<0.01〕. The levels of hs-CRP, TLR2, TLR4 and sST2 were gradually increased along with the increases of Canadian Cardiovascular Society Angina Pectoris Grade and cardiac function classification of the American College of Cardiology (all P<0.01). Conclusions Serum level changes in hs-CRP, TLR2, TLR4 and sST2 in elderly patients with old myocardial infarction may become the new indicators to forecast the degree of old myocardial infarction. Key words: C-reactive protein; Toll-like receptors; Myocardial infarction
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".