Case of a Long-Time Survivor with Recurrent Multiple Brain Metastases from Lung Cancer: Terminal Stage Cancer or Chronic Disease
Bibliographic record
Abstract
Lung cancer with brain metastasis has a poor prognosis and has always been treated with palliative intent in the past. We report a case of good response to two courses of whole brain irradiation (WBI) and one course of hypofractionated stereotactic radiotherapy (HSRT) over a nine-year period, with no significant neurotoxicity. We present the case of a 43-year-old non-smoker female with biopsy-proven adenocarcinoma of right lower lobe lung, stage T1N2M0, positive for anaplastic lymphoma kinase (ALK). She received concurrent 60-Gy chemoradiation in 30 fractions in 2010. She had no local recurrence, but biopsy confirmed distant metastases in neck lymph nodes nine months later. As a result of a 3-cm brain metastasis in the right cerebellum on computed tomography (CT), she received 20-Gy WBI in five fractions. We did not treat any other distant metastases with radiation. She only received systemic tyrosine kinase inhibitors (TKIs). Four years after the first WBI, she developed headaches and balance problem. MRI showed at least nine metastatic lesions in the brain. She had a craniotomy to remove the largest 4-cm lesion in the right cerebellum followed by 21-Gy WBI in seven fractions. Her symptoms disappeared, and she went back to her normal life. Another MRI three years after the second WBI showed progression of the largest brain metastases in the right cerebellum. We offered her 20-Gy HSRT in five fractions every other day. She tolerated HSRT very well, with no neurotoxicity. She was able to walk without a walker or cane. She could manage all her daily activities. On examination, there was no neurological deficit. CT scan nine months after HSRT showed excellent local control. Stage 4 non-small cell lung cancer with positive ALK can have a good response to TKI, and long survival is possible even with multiple brain metastases. Not all patients will have severe neurotoxicity after multiple courses of WBI. HSRT can be a good alternative treatment to symptomatic brain metastases if craniotomy is not desirable. The acute and late toxicities can be reasonably tolerated. Long-term local control and good quality of life are achievable.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".