Treatment of knee osteoarthritis with mixture of platelet-rich-plasma plus hyaluronic acid
Bibliographic record
Abstract
Objective To compare the clinic effects of intra-knee-articular injection of PRP+ HA mixture and PRP only on treating grade Ⅱand Ⅲ knee osteoarthritis. Methods A total of 126 qualified patients with grade Ⅱ and Ⅲknee osteoarthritis according to Keligren Lawrence classification(K-L classification ) in Weihai Municipal Hospital and Shandong Provincial hospital from February 2014 to May 2014 were included: Exclusion criteria were other knee inflammatory diseases, any bone and joint tumors, history of hormone usage, and severe cardiovascular diseases and diabetes. There were 63 cases in the PRP+ HA mixture group and 63 cases in the PRP group. The pain was evaluated by visual analogue scale (VAS), and the joint function was assessed with Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC). The t-test was used to asscesse the difference of age, body mass index(BMI), visual analogue score (VAS) and WOMAC scores; chi-square test was used to evaluate the difference of gender, K-L classification. Follow-up was carried out at one, three, six and 12 months. VAS score and WOMAC score were assessed the patients’ condition. The t test was used to compare the curative effect at different time points after the treatment. Results There was no significant difference between the two groups in gender, age, or BMI (all P>0.05). In the participants treated with PRP+ HA mixture and with PRP only, VAS scores decreased significantly, and accordingly, knee function (WOMAC) improved, compared to the status of patients prior to treatment. Regarding to VAS and WOMAC, no significant difference was observed between the two groups (VAS: t=0.862, P>0.05; WOMAC: t=1.765, P>0.05); however, there was a trend that could obtain better functional scores in PRP+ HA mixture group. No major adverse events or complications were observed in both groups. Conclusion PRP+ HA mixture is effective and safe in the management of patients suffering from grade Ⅱ and Ⅲ KOA. Key words: Osteoarthritis; Platelet rich plasma; Hyaluronic acid
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".