Serum level of 25-hydroxy vitamin D3 and its correlations with sleep quality and cognition in patients with chronic insomnia disorder
Bibliographic record
Abstract
Objective To explore serum level of 25-hydroxy vitamin D3 (25[OH]D3) and its correlations with sleep quality and cognitive function in patients with chronic insomnia disorder (CID). Methods Fifty CID patients, admitted to our hospital from October 1, 2016 to September 1, 2018, and 40 healthy controls were enrolled. Pittsburgh Sleep Quality Index (PSQI) was used to assess insomnia severity (objective sleep status being assessed using polysomnography throughout a night in some patients). Montreal Cognitive Assessment scale (MoCA) was used to evaluate the general cognitive function. Serum level of 25(OH)D3 was detected by ELISA. Results As compared with the controls, CID patients had significantly higher PSQI scores (P<0.05) and statistically higher Hamilton's Depression Scale-17 scores (P<0.05). The CID patients had significantly lower MoCA scores, having more errors in object work, spatial work and object recognition memorizes in Nine-Box Maze Test than the controls. Partial correlation analysis showed that in CID patients, the level of 25(OH)D3 was negatively correlated with PSQI scores (r=-0.320, P=0.030), spatial working memory errors (r=-0.300, P=0.043) and disease course (r=-0.360, P=0.014), whereas it was positively correlated with total sleep time (r=0.515, P=0.014) and MoCA scores (r=0.422, P=0.003). Conclusion The level of 25(OH)D3 decreases in the CID patients, which is correlated with insomnia severity and course, and may affect the cognitive function. Key words: Insomnia; 25-hydroxy vitamin D3; Cognitive function
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".