Efficacy of platelet-rich plasma combined with arthroscopic debridement for treatment of knee osteoarthritis
Bibliographic record
Abstract
Objective To investigate the clinical effects of platelet-rich plasma (PRP) in combination with arthroscopic debridement for moderate knee osteoarthritis. Methods A total of 25 patients with grade two or grade three knee osteoarthritis according to K-L classification, numerical rating scal (NRS) over five, failed treatment with non-operative methods for more than three months were allocated in the treatment group(n=12) or the control group(n=13). In the treatment group, two times of 5 ml of PRP intra-articular injection were performed with four weeks interval. The first time of PRP intra-articular injection was performed during arthroscopy after arthroscopic debridement. In the control group, the patients were only treated with knee arthroscopic debridement. The outcomes were assessed with NRS, Western Ontario and McMaster Universities osteoarthritis index (WOMAC), the Hospital for Special Surgery (HSS) scores, the short form-36 questionnaire of health survey (SF-36) scores at baseline and six months, one year and two years after treatment. Statistical analysis was performed using the SPSS version 17.0. Data of Gaussian distribution were analyzed by ttest (data between treatment and control groups) or analysis of variance (data within group). Categorized data were analyzed using the Chi-square test. Results The scores of NRS and WOMAC of the treatment group at six months, one year and two years after treatment were lower than the control group; the scores of HSS and SF-36 of the treatment group were higher than the control group. In the treatment group, the scores of NRS and WOMAC at six months after treatment decreased from (7.1±1.0), (74.4±11.1) at baseline to (1.3±0.6)(t=13.415, P 0.05), while the scores of WOMAC and SF-36 at two years after treatment were (21.7±2.7)(t=15.517, P 0.05). Conclusions Both the PRP and arthroscopic debridement could reduce pain, restore knee function and improve the life quality of patients with knee osteoarthritis of K-L grade two and three. The PRP combined with arthroscopic debridement may have better and long-term effects of pain reduction, knee function restoration and life quality improvement within two years compared to arthroscopic debridement alone. The effects of the arthroscopic debridement could maintain for only six months. Key words: Platelet-rich plasma; Arthroscopy; Osteoarthritis; Knee; Treatment outcome
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".