Improvement effect of recombinant human erythropoietin on cognition disorders in acute brain infarction patients
Bibliographic record
Abstract
Objective To study the improvement effect of recombinant human erythropoietin (rHu-EPO) on cognition disorders in acute brain infarction patients. Methods Acute brain infarction patients with cognition disorders were randomly divided into the control group (16 cases) and rHu-EPO group (18 cases), and two cases in each group were initiatively dropped out during therapy. Patients in the control group received conventional treatment, and patients in the rHu-EPO group were given subcutaneous injection of 30 IU/kg rHu-EPO 3 times per week, and lasted for 4 weeks additionally. Montreal cognitive assessment scales (MOCA) were used to evaluate cognitive function, neural function defect were scaled according to the national institutes of health neurological deficit score (NIHSS) and infarction sizes were determined by magnetic resonance imaging before and after therapy. Results Compared with before therapy, the MOCA score (t = 1.684, P = 0.035; t = 3.622, P = 0.011), language function scores (t = 2.258, P = 0.025; t = 3.472, P = 0.019) and delayed memory function scores (t = 2.665, P = 0.018; t = 4.826, P = 0.026) in the control group and rHu-EPO group all increased markedly, and the MOCA score [(20.21 ± 2.63) vs. (16.99 ± 2.28); t = 4.183, P = 0.011], language function scores [(2.76 ± 0.83) vs. (1.66 ± 0.71); t = 4.865, P = 0.008] and delayed memory function scores [(4.66 ± 1.38) vs. (3.12 ± 1.02); t = 2.643, P = 0.025] in the rHu-EPO group were much higher than those in the control group. After therapy, the NIHSS in the control group and rHu-EPO group were also lower than those before therapy (t = 3.506, 8.126, P = 0.018, 0.002), and in the rHu-EPO group reduced obviously as compared with that in the control group (t = 2.508, P = 0.026). Meanwhile, the infarction sizes after therapy only in the rHu-EPO group decreased as compared with before therapy [(12.8 ± 3.5) cm3 vs. (8.2 ± 2.3) cm3; t = 6.204, P = 0.001], and in the rHu-EPO group were much smaller than those in the control group (t = 3.268, P = 0.022). Conclusion Based on conventional therapy, rHu-EPO may effectively improve cognition disorders in acute brain infarction patients, especially language and delayed memory function. Key words: Brain infarction; Cognition disorders; Recombinant human erythropoietin
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".